Rr320^tm3.1Mkg
Targeted Allele Detail

Summary

• Symbol: Rr320^tm3.1Mkg
• Name: regulatory region 320; targeted mutation 3.1 Mark Groudine
• MGI ID: MGI:3525615
• Synonyms: delta5,6deltaH, Hbb-ar^tm3.1Mkg
• Gene: Rr320 Location: Chr7:103501973-103526752 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Rr320^tm3.1Mkg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51229
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The 5'DNAse I hypersensitive sites 5 and 6 were replaced with a loxP site flanked hygromycin resistance gene cassette. Upon crossing with CMV-cre deleter mice, the hygro cassette was excised, leaving a single loxP site in place of 5' HS5 and 6. (J:51229)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr320 Mutation: 0 strains or lines available

References

• Original: J:51229 Bender MA, et al., Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse beta-globin locus control region. Blood. 1998 Dec 1;92(11):4394-403
• All: 2 reference(s)