Inpp5d^tm1.1Wgk
Targeted Allele Detail

Summary

• Symbol: Inpp5d^tm1.1Wgk
• Name: inositol polyphosphate-5-phosphatase D; targeted mutation 1.1, William G Kerr
• MGI ID: MGI:3525663
• Synonyms: SHIP^-
• Gene: Inpp5d Location: Chr1:87548034-87648229 bp, + strand Genetic Position: Chr1, 44.44 cM, cytoband C5
• Alliance: Inpp5d^tm1.1Wgk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95215
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Crossing with cre deleter mice excised the floxed region containing the promoter and exon 1. Western blot of spleen whole cell lysates demonstrated a lack of protein in mutants. (J:95215)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Inpp5d Mutation: 94 strains or lines available

References

• Original: J:95215 Wang JW, et al., Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science. 2002 Mar 15;295(5562):2094-7
• All: 15 reference(s)