Obsty3^LG/J
QTL Variant Detail

Summary

• QTL variant: Obsty3^LG/J
• Name: obesity 3; LG/J
• MGI ID: MGI:3525677
• QTL: Obsty3 Location: Chr10:8235478-116190980 bp Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: LG/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased obesity compared to SM/J. (J:94605)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94605

Linkage analysis was performed on 16 LGXSM (LG=LG/J; SM=SM/J) recombinant inbred (RI) lines to identify QTLs associated with obesity and diabetes traits. Parental strain LG/J exhibits a larger body size compared to parental strain SM/J and these two strains also differ in obesity and diabetes related traits in response to dietary fat. 506 microsatellite markers at an average spacing of 2 to 3 cM were used in the genome scan. 39 loci were mapped but only those reaching genomewide significance are reportedhere.

On mouse Chromosome 10, an interval between D10Mit295 (63 cM) and D10Mit305 shows linkage to total fat pad weight, renal, mesenteric, and inguinal fat pad weights, body weight at necropsy, and heart weight. This locus is named Obsty3 (obesity 3). LG/J-derived alleles confer increased fat pad weights at this locus. Obsty3 also shows suggestive linkage to liver weight on a high fat diet. Potential candidate genes mapping near Obsty3 are Frs2, Avpr1a, and Tph2.

References

• Original: J:94605 Cheverud JM, et al., Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes. 2004 Dec;53(12):3328-36
• All: 1 reference(s)