Fezf2^tm1Skm
Targeted Allele Detail

Summary

• Symbol: Fezf2^tm1Skm
• Name: Fez family zinc finger 2; targeted mutation 1, Susan K McConnell
• MGI ID: MGI:3525887
• Synonyms: Fezf2-PLAP, Fezf2^PLAP
• Gene: Fezf2 Location: Chr14:10121574-10127669 bp, + strand Genetic Position: Chr14, 6.36 cM
• Alliance: Fezf2^tm1Skm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103829
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence is replaced by EGFP-IRES-PLAP. PGK-neo selection cassette is floxed and has been removed. EGFP is not expressed in hets or mutants, but PLAP is expressed. Absence of transcription was confirmed by in situ hybridization. (J:103829)

Expression

In Mice Carrying this Mutation:	103 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fezf2 Mutation: 49 strains or lines available

Notes

ES cell line = E14a

References

• Original: J:103829 Chen B, et al., Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17184-9
• All: 13 reference(s)