Kcna2^tm1Tem
Targeted Allele Detail

Summary

• Symbol: Kcna2^tm1Tem
• Name: potassium voltage-gated channel, shaker-related subfamily, member 2; targeted mutation 1, Bruce L Tempel
• MGI ID: MGI:3526017
• Gene: Kcna2 Location: Chr3:107008462-107022321 bp, + strand Genetic Position: Chr3, 46.61 cM
• Alliance: Kcna2^tm1Tem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131735
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the entire open reading frame. mRNAQ cannot be found by quantitative PCR and protein product cannot be identified by Western blot in extracts from homozygous mutant mice. (J:131735)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcna2 Mutation: 43 strains or lines available

References

• Original: J:131735 Brew HM, et al., Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons. J Neurophysiol. 2007 Sep;98(3):1501-25
• All: 7 reference(s)