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Cd207tm1Mal
Targeted Allele Detail
Summary
Symbol: Cd207tm1Mal
Name: CD207 antigen; targeted mutation 1, Bernard Malissen
MGI ID: MGI:3526083
Gene: Cd207  Location: Chr6:83648197-83654839 bp, - strand  Genetic Position: Chr6, 35.94 cM, cytoband D1-D2
Alliance: Cd207tm1Mal page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95147
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace all of exons 1-3 and part of exon 4 with a neomycin resistance gene cassette. Immunohistochemistry confirmed a lack of protein in epidermal samples of mutants. (J:95147)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd207 Mutation:  25 strains or lines available
References
Original:  J:95147 Kissenpfennig A, et al., Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function. Mol Cell Biol. 2005 Jan;25(1):88-99
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory