Cd207^tm1Mal
Targeted Allele Detail

Summary

• Symbol: Cd207^tm1Mal
• Name: CD207 antigen; targeted mutation 1, Bernard Malissen
• MGI ID: MGI:3526083
• Gene: Cd207 Location: Chr6:83648197-83654839 bp, - strand Genetic Position: Chr6, 35.94 cM, cytoband D1-D2
• Alliance: Cd207^tm1Mal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95147
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace all of exons 1-3 and part of exon 4 with a neomycin resistance gene cassette. Immunohistochemistry confirmed a lack of protein in epidermal samples of mutants. (J:95147)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd207 Mutation: 25 strains or lines available

References

• Original: J:95147 Kissenpfennig A, et al., Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function. Mol Cell Biol. 2005 Jan;25(1):88-99
• All: 1 reference(s)