Ghr^tm2Mwat
Targeted Allele Detail

Summary

• Symbol: Ghr^tm2Mwat
• Name: growth hormone receptor; targeted mutation 2, Michael J Waters
• MGI ID: MGI:3526105
• Synonyms: m391
• Gene: Ghr Location: Chr15:3347237-3612834 bp, - strand Genetic Position: Chr15, 1.84 cM
• Alliance: Ghr^tm2Mwat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95149
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A targeting vector was designed to result in truncation of the protein at lysine 391. Northern blot of hepatic tissue confirmed successful targeting. (J:95149)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghr Mutation: 50 strains or lines available

References

• Original: J:95149 Rowland JE, et al., In vivo analysis of growth hormone receptor signaling domains and their associated transcripts. Mol Cell Biol. 2005 Jan;25(1):66-77
• All: 5 reference(s)