Plcl1^tm1Mh
Targeted Allele Detail

Summary

• Symbol: Plcl1^tm1Mh
• Name: phospholipase C-like 1; targeted mutation 1, Masato Hirata
• MGI ID: MGI:3526123
• Synonyms: p130^-, PRIP-1^-, PRIP-1 KO
• Gene: Plcl1 Location: Chr1:55445080-55793444 bp, + strand Genetic Position: Chr1, 28.15 cM
• Alliance: Plcl1^tm1Mh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92489
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A fragment of coding sequence spanning residues 82-826 of the protein was replaced with a neo. RT-PCR and immunoblot confirmed successful targeting in mutant brains. Protein activity was virtually absent in mutant brains as shown by a binding assay. (J:92489)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plcl1 Mutation: 54 strains or lines available

References

• Original: J:92489 Kanematsu T, et al., Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. EMBO J. 2002 Mar 1;21(5):1004-11
• All: 17 reference(s)