Chrna2^tm1Jbou
Targeted Allele Detail

Summary

• Symbol: Chrna2^tm1Jbou
• Name: cholinergic receptor nicotinic alpha 2 subunit; targeted mutation 1, Jim Boulter
• MGI ID: MGI:3526149
• Synonyms: alpha2^-
• Gene: Chrna2 Location: Chr14:66372488-66390397 bp, + strand Genetic Position: Chr14, 34.36 cM
• Alliance: Chrna2^tm1Jbou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126075
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted in exon 5. The presence of the null allele was confirmed by genomic PCR and brain region-specific RT-PCR. (J:197153)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrna2 Mutation: 33 strains or lines available

References

• Original: J:126075 Nakauchi S, et al., Nicotine gates long-term potentiation in the hippocampal CA1 region via the activation of alpha2* nicotinic ACh receptors. Eur J Neurosci. 2007 May;25(9):2666-81
• All: 10 reference(s)