Rai1^tm1Jrl
Targeted Allele Detail

Summary

• Symbol: Rai1^tm1Jrl
• Name: retinoic acid induced 1; targeted mutation 1, James R Lupski
• MGI ID: MGI:3526160
• Synonyms: Rai1-
• Gene: Rai1 Location: Chr11:59995839-60090023 bp, + strand Genetic Position: Chr11, 37.81 cM, cytoband B2
• Alliance: Rai1^tm1Jrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98073
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An approximately 4.0 kb of the coding region in exon 2 was replaced by an intra-ribosomal entry site IRES-lacZ-pA cassette followed by a loxP flanked PGKneobpA cassette. RT-PCR indicated that only sequence 5' of the deleted region was present in transcripts. This truncation eliminates all nuclear localization regions and the PHD domain. (J:98073)

Disease models

Expression

In Mice Carrying this Mutation:	65 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rai1 Mutation: 73 strains or lines available

References

• Original: J:98073 Bi W, et al., Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome. Hum Mol Genet. 2005 Apr 15;14(8):983-95
• All: 10 reference(s)