Sycp2^tm1Jw
Targeted Allele Detail

Summary

• Symbol: Sycp2^tm1Jw
• Name: synaptonemal complex protein 2; targeted mutation 1, Jeremy Wang
• MGI ID: MGI:3526164
• Gene: Sycp2 Location: Chr2:177987086-178049478 bp, - strand Genetic Position: Chr2, 99.81 cM, cytoband H4
• Alliance: Sycp2^tm1Jw page

Meiotic arrest and apoptosis of spermatocytes in Sycp2^tm1Jw/Sycp2^tm1Jw mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111287
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exons 39-43 were replaced by the PGK1-Neo selection marker. RT-PCR demonstrated expression of a transcript resulting from exon 38 splicing to exon 44. Protein was expressed in mutants, resulting from the shorter, mutant transcript. (J:111287)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sycp2 Mutation: 84 strains or lines available

References

• Original: J:111287 Yang F, et al., Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol. 2006 May 22;173(4):497-507
• All: 3 reference(s)