Nxf2^tm1.1Jw
Targeted Allele Detail

Summary

• Symbol: Nxf2^tm1.1Jw
• Name: nuclear RNA export factor 2; targeted mutation 1.1, Jeremy Wang
• MGI ID: MGI:3526168
• Synonyms: Nxf2^fl
• Gene: Nxf2 Location: ChrX:133845275-133865503 bp, - strand Genetic Position: ChrX, 56.31 cM
• Alliance: Nxf2^tm1.1Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149228
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a floxed hygro cassette was inserted downstream of exon 11. Transient cre expression in ES cells removed the hygro cassette. (J:149228)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nxf2 Mutation: 4 strains or lines available

References

• Original: J:149228 Pan J, et al., Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia. Dev Biol. 2009 Jun 1;330(1):167-74
• All: 2 reference(s)