Map3k11^tm1Rjd
Targeted Allele Detail

Summary

• Symbol: Map3k11^tm1Rjd
• Name: mitogen-activated protein kinase kinase kinase 11; targeted mutation 1, Roger J Davis
• MGI ID: MGI:3526217
• Synonyms: Mlk3^-
• Gene: Map3k11 Location: Chr19:5738770-5752893 bp, + strand Genetic Position: Chr19, 4.34 cM
• Alliance: Map3k11^tm1Rjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97631
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was created by the replacement of exons 2-5, which encode the kinase domain, with a neomycin resistance gene. Immunoblot of mutant MEFs confirmed absence of protein. (J:97631)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k11 Mutation: 32 strains or lines available

References

• Original: J:97631 Brancho D, et al., Role of MLK3 in the Regulation of Mitogen-Activated Protein Kinase Signaling Cascades. Mol Cell Biol. 2005 May;25(9):3670-81
• All: 15 reference(s)