Agxt^tm1Ull
Targeted Allele Detail

Summary

• Symbol: Agxt^tm1Ull
• Name: alanine-glyoxylate aminotransferase; targeted mutation 1, Eduardo C Salido
• MGI ID: MGI:3526219
• Synonyms: AgtKO
• Gene: Agxt Location: Chr1:93062962-93073143 bp, + strand Genetic Position: Chr1, 47.0 cM
• Alliance: Agxt^tm1Ull page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117145
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene was used to replace exons 4-8 of the locus. Absence of protein was confirmed by Western blot analysis. (J:117145)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agxt Mutation: 16 strains or lines available

References

• Original: J:117145 Salido EC, et al., Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18249-54
• All: 11 reference(s)