Hmox1^tm1.1Gkl
Targeted Allele Detail

Summary

• Symbol: Hmox1^tm1.1Gkl
• Name: heme oxygenase 1; targeted mutation 1.1, George Kollias
• MGI ID: MGI:3526228
• Synonyms: Hmox1^FL
• Gene: Hmox1 Location: Chr8:75820249-75827217 bp, + strand Genetic Position: Chr8, 35.59 cM, cytoband C1
• Alliance: Hmox1^tm1.1Gkl page

Hmox1^tm1.1Gkl/Hmox1^tm1.1Gkl Lyz2^tm1(cre)Ifo/Lyz2⁺ mice show decreased susceptibility to L. monocytogenes infection

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148498
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A floxed neo cassette was inserted downstream of exon 2, and an additional loxP site was inserted downstream of exon 4. Germ line, cre mediated recombination was used to remove the neo cassette leaving exons 2 through 4 floxed.

Generation of Hmox1^tm1.1Gkl and Hmox1^tm1.2Gkl alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hmox1 Mutation: 35 strains or lines available

Notes

ES cell line = "129/3."

References

• Original: J:148498 Tzima S, et al., Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med. 2009 May 11;206(5):1167-79
• All: 7 reference(s)