Rad9b^tm1Lieb
Targeted Allele Detail

Summary

• Symbol: Rad9b^tm1Lieb
• Name: RAD9 checkpoint clamp component B; targeted mutation 1, Howard B Lieberman
• MGI ID: MGI:3526236
• Synonyms: Mrad9b^-
• Gene: Rad9b Location: Chr5:122461286-122492296 bp, - strand Genetic Position: Chr5, 62.3 cM
• Alliance: Rad9b^tm1Lieb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165426
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 as well as 500 bp upstream of the start codon were replaced with a floxed neo cassette. Northern blot analysis confirmed the absence of transcription. (J:165426)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad9b Mutation: 28 strains or lines available

References

• Original: J:165426 Leloup C, et al., Mouse Rad9b is essential for embryonic development and promotes resistance to DNA damage. Dev Dyn. 2010 Nov;239(11):2837-50
• All: 1 reference(s)