Dlk1^tm1Srba
Targeted Allele Detail

Summary

• Symbol: Dlk1^tm1Srba
• Name: delta like non-canonical Notch ligand 1; targeted mutation 1, Steven R Bauer
• MGI ID: MGI:3526402
• Gene: Dlk1 Location: Chr12:109418749-109429262 bp, + strand Genetic Position: Chr12, 60.17 cM, cytoband E-F1
• Alliance: Dlk1^tm1Srba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145076
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3 of this imprinted gene were replaced with a neomycin resistance cassette. No mRNA from this locus was detected in the neonatal liver of homozygotes or in heterozygotes that have paternally-inherited the mutant allele. (J:145076)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlk1 Mutation: 34 strains or lines available

References

• Original: J:145076 Raghunandan R, et al., Dlk1 influences differentiation and function of B lymphocytes. Stem Cells Dev. 2008 Jun;17(3):495-507
• All: 18 reference(s)