Zap70^st
Spontaneous Allele Detail

Summary

• Symbol: Zap70^st
• Name: zeta-chain (TCR) associated protein kinase; strange
• MGI ID: MGI:3526403
• Gene: Zap70 Location: Chr1:36800912-36821899 bp, + strand Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
• Alliance: Zap70^st page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: RT-PCR and sequence analysis revealed eight nucleotide differences relative to wild-type sequence. Seven were silent and one, a C-to-T transition, caused an arginine to cystein change at position 464 (p.R464C), thereby disrupting the conserved DLAARN motif within the kinase domain. (J:41170)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zap70 Mutation: 55 strains or lines available

References

• Original: J:41170 Wiest DL, et al., A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity. 1997 Jun;6(6):663-71
• All: 2 reference(s)