Stx2^tm1Dcru
Targeted Allele Detail

Summary

• Symbol: Stx2^tm1Dcru
• Name: syntaxin 2; targeted mutation 1, Deborah C Rubin
• MGI ID: MGI:3526405
• Synonyms: epimorphin^-
• Gene: Stx2 Location: Chr5:129061621-129085638 bp, - strand Genetic Position: Chr5, 67.99 cM
• Alliance: Stx2^tm1Dcru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110376
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The initiator methionine and coding region of exon 1 were replaced with GFP and a floxed neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of protein in the small intestine, colon, kidney, liver, and testis of homozygous mice. (J:110376)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stx2 Mutation: 24 strains or lines available

References

• Original: J:110376 Wang Y, et al., Epimorphin mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis. J Clin Invest. 2006 Jun;116(6):1535-46
• All: 6 reference(s)