Flnc^tm1Lmk
Targeted Allele Detail

Summary

• Symbol: Flnc^tm1Lmk
• Name: filamin C, gamma; targeted mutation 1, Louis M Kunkel
• MGI ID: MGI:3526406
• Gene: Flnc Location: Chr6:29433255-29461882 bp, + strand Genetic Position: Chr6, 12.36 cM
• Alliance: Flnc^tm1Lmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112170
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin selection cassette replaced 4.1kb of the gene, including the last eight exons (41-48). Western blot analysis on muscle lysates derived from homozygous mice indicated that a truncated protein is expressed at low levels from this allele. (J:112170)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Flnc Mutation: 131 strains or lines available

References

• Original: J:112170 Dalkilic I, et al., Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure. Mol Cell Biol. 2006 Sep;26(17):6522-34
• All: 2 reference(s)