Ctsg^{tm2.1(PML/RARA)Ley}
Targeted Allele Detail

Summary

• Symbol: Ctsg^{tm2.1(PML/RARA)Ley}
• Name: cathepsin G; targeted mutation 2.1, Timothy J Ley
• MGI ID: MGI:3526413
• Synonyms: Ctsg^tm2.1Ley, mCG^PML-RARalpha, mCG^PR(deltaPGK-neo), PR^WT
• Gene: Ctsg Location: Chr14:56337342-56340031 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Ctsg^{tm2.1(PML/RARA)Ley} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84230
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Ctsg^{tm2.1(PML/RARA)Ley} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PML (5371)

  Pml	(MGI:104662)

  human

  RARA (5914)

  Rara	(MGI:97856)

• Mutation details: A human cDNA encoding the PML-RARalpha fusion and a loxP flanked PGK-neo was inserted into the 5' UTR. Transient Cre expression removed the floxed PGK-neo. (J:84230)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Ctsg^{tm2.1(PML/RARA)Ley}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsg Mutation: 13 strains or lines available

References

• Original: J:84230 Westervelt P, et al., High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. Blood. 2003 Sep 1;102(5):1857-65
• All: 17 reference(s)