Wnt9b^tm1.1Amc
Targeted Allele Detail

Summary

• Symbol: Wnt9b^tm1.1Amc
• Name: wingless-type MMTV integration site family, member 9B; targeted mutation 1.1, Andrew P McMahon
• MGI ID: MGI:3526437
• Synonyms: Wnt9b^-, Wnt9bⁿ
• Gene: Wnt9b Location: Chr11:103618190-103640647 bp, - strand Genetic Position: Chr11, 67.47 cM
• Alliance: Wnt9b^tm1.1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100575
• Parent Cell Line: AV3 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated excision of exon 2 in Wnt9b^tm1Amc resulted in the out of frame fusion of exon 1 and 3. The putative nonfunctional peptide would contain only the first 27 amino acids that comprise the signal peptide. (J:100575)

Expression

In Mice Carrying this Mutation:	8 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt9b Mutation: 23 strains or lines available

References

• Original: J:100575 Carroll TJ, et al., Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell. 2005 Aug;9(2):283-92
• All: 15 reference(s)