Aqp7^tm1Tfun
Targeted Allele Detail

Summary

• Symbol: Aqp7^tm1Tfun
• Name: aquaporin 7; targeted mutation 1, Tohru Funahashi
• MGI ID: MGI:3526441
• Synonyms: Aqp7^-
• Gene: Aqp7 Location: Chr4:41033074-41048139 bp, - strand Genetic Position: Chr4, 20.83 cM, cytoband B1
• Alliance: Aqp7^tm1Tfun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95278
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced 8 kb of sequence including exon 1-3 and the translation start sites. Northern blot analysis of WAT, BAT, kidney and liver of mutant mice demonstrated successful gene ablation. (J:95278)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aqp7 Mutation: 24 strains or lines available

References

• Original: J:95278 Maeda N, et al., Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17801-6
• All: 6 reference(s)