Apex2^tm1Yun
Targeted Allele Detail

Summary

• Symbol: Apex2^tm1Yun
• Name: apurinic/apyrimidinic endonuclease 2; targeted mutation 1, Yusaku Nakabeppu
• MGI ID: MGI:3526443
• Gene: Apex2 Location: ChrX:149302515-149372864 bp, - strand Genetic Position: ChrX, 68.46 cM, cytoband F2
• Alliance: Apex2^tm1Yun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95267
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the 3' end of intron 5 and the 5' end of exon 6 with a neo in the opposite orientation. Northern blot showed that mutant ES cells did not contain wild-type transcript. (J:82005)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apex2 Mutation: 6 strains or lines available

References

• Original: J:95267 Ide Y, et al., Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice. Blood. 2004 Dec 15;104(13):4097-103
• All: 8 reference(s)