Spred1^tm1Hiin
Targeted Allele Detail

Summary

• Symbol: Spred1^tm1Hiin
• Name: sprouty protein with EVH-1 domain 1, related sequence; targeted mutation 1, Hiromasa Inoue
• MGI ID: MGI:3526452
• Synonyms: Spred-1^-
• Gene: Spred1 Location: Chr2:116951855-117012760 bp, + strand Genetic Position: Chr2, 59.03 cM, cytoband E5
• Alliance: Spred1^tm1Hiin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95263
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced much of exon 4, including the sequence encoding the kit-binding domain and Sprouty-related COOH-terminal cystein-rich domains. RT-PCR confirmed the lack of transcript in mutant brain samples, and Western blot showed the lack of protein in mutant brain, liver, and kidney samples. (J:95263)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spred1 Mutation: 38 strains or lines available

References

• Original: J:95263 Inoue H, et al., Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness. J Exp Med. 2005 Jan 3;201(1):73-82
• All: 7 reference(s)