Rsc1a1^tm1Koep
Targeted Allele Detail

Summary

• Symbol: Rsc1a1^tm1Koep
• Name: regulatory solute carrier protein, family 1, member 1; targeted mutation 1, Hermann Koepsell
• MGI ID: MGI:3526519
• Synonyms: RS1^-
• Gene: Rsc1a1 Location: Chr4:141411162-141412910 bp, - strand Genetic Position: Chr4, 74.7 cM
• Alliance: Rsc1a1^tm1Koep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95148
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced by a neomycin selection cassette in reverse orientation. Northern blot of kidney samples from mutants demonstrated the absence of wild-type mRNA. Western blot indicated the absence of protein in mutant kidney and intestine. (J:95148)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rsc1a1 Mutation: 8 strains or lines available

References

• Original: J:95148 Osswald C, et al., Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol Cell Biol. 2005 Jan;25(1):78-87
• All: 3 reference(s)