Sdhd^tm1Jlob
Targeted Allele Detail

Summary

• Symbol: Sdhd^tm1Jlob
• Name: succinate dehydrogenase complex, subunit D, integral membrane protein; targeted mutation 1, Jose Lopez-Barneo
• MGI ID: MGI:3526521
• Synonyms: SDHD^-
• Gene: Sdhd Location: Chr9:50507657-50515112 bp, - strand Genetic Position: Chr9, 27.75 cM, cytoband B
• Alliance: Sdhd^tm1Jlob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95252
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2-4 were replaced with a neomycin resistance gene. (J:95252)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sdhd Mutation: 16 strains or lines available

References

• Original: J:95252 Piruat JI, et al., The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia. Mol Cell Biol. 2004 Dec;24(24):10933-40
• All: 7 reference(s)