Homer1^tm1Mhd
Targeted Allele Detail

Summary

• Symbol: Homer1^tm1Mhd
• Name: homer scaffolding protein 1; targeted mutation 1, Marlin H Dehoff
• MGI ID: MGI:3526529
• Synonyms: H1ko
• Gene: Homer1 Location: Chr13:93436143-93541637 bp, + strand Genetic Position: Chr13, 47.83 cM
• Alliance: Homer1^tm1Mhd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95212
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: One loxP site was inserted 200 bp upstream of exon 2 and an SV40-neo cassette flanked with frt sites and containing an additional loxP site was inserted 700 bp downstream of exon 2. The neomycin insert was subsequently removed by crossing to Flpe transgenic mice after which exon 2 was excised by crossing to CMV-cre transgenic mice. (J:95212)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Homer1 Mutation: 25 strains or lines available

References

• Original: J:95212 Yuan JP, et al., Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell. 2003 Sep 19;114(6):777-89
• All: 20 reference(s)