Homer2^tm1Mhd
Targeted Allele Detail

Summary

• Symbol: Homer2^tm1Mhd
• Name: homer scaffolding protein 2; targeted mutation 1, Marlin H Dehoff
• MGI ID: MGI:3526530
• Synonyms: H2ko
• Gene: Homer2 Location: Chr7:81250229-81356673 bp, - strand Genetic Position: Chr7, 45.71 cM
• Alliance: Homer2^tm1Mhd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95213
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin gene was inserted in inverse orientation into exon 3. mRNA and protein products could not be detected. (J:95213)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Homer2 Mutation: 22 strains or lines available

References

• Original: J:95213 Shin DM, et al., Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J Cell Biol. 2003 Jul 21;162(2):293-303
• All: 14 reference(s)