Thy1^tm1Kak
Targeted Allele Detail

Summary

• Symbol: Thy1^tm1Kak
• Name: thymus cell antigen 1, theta; targeted mutation 1, Kevin A Kelley
• MGI ID: MGI:3526563
• Synonyms: Thy-1^-
• Gene: Thy1 Location: Chr9:43954681-43959876 bp, + strand Genetic Position: Chr9, 24.52 cM
• Alliance: Thy1^tm1Kak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95210
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence, from the ATG initiation site in exon 2 through exon 4, was replaced with a PGK-neomycin cassette. Northern blot analysis confirmed the absence of transcription. (J:95210)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thy1 Mutation: 211 strains or lines available

Notes

ES cell line = RW4 (129X1/SvJ) or J1 (129S4/SvJae).

References

• Original: J:95210 Barlow JZ, et al., Testing the role of the cell-surface molecule Thy-1 in regeneration and plasticity of connectivity in the CNS. Neuroscience. 2002;111(4):837-52
• All: 1 reference(s)