Hbb-b1^tm1Ley
Targeted Allele Detail

Summary

• Symbol: Hbb-b1^tm1Ley
• Name: hemoglobin, beta adult major chain; targeted mutation 1, Timothy J Ley
• MGI ID: MGI:3526656
• Gene: Hbb-b1 Location: unknown Genetic Position: Chr7, 54.85 cM
• Alliance: Hbb-b1^tm1Ley page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70187
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A mutation was introduced which caused an alanine to isoleucine change at amino acid residue 6 of the protein (A6I). A PGK-neomycin resistance cassette was also integrated at a downstream location. (J:70187)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hbb-b1 Mutation: 7 strains or lines available

References

• Original: J:70187 Kaufman RM, et al., Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine beta-major and beta-minor globin genes. Blood. 2001 Jul 1;98(1):65-73
• All: 1 reference(s)