Pbrm1^tm1Rtj
Targeted Allele Detail

Summary

• Symbol: Pbrm1^tm1Rtj
• Name: polybromo 1; targeted mutation 1, Robert Tjian
• MGI ID: MGI:3526660
• Synonyms: BAF180^-
• Gene: Pbrm1 Location: Chr14:30741095-30843549 bp, + strand Genetic Position: Chr14, 19.09 cM, cytoband B
• Alliance: Pbrm1^tm1Rtj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95332
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing predicted exon 11 was replaced with an in frame beta-galactosidase-neomycin phosphotransferase fusion gene (beta-geo). A fusion protein is expressed under the contol of the endogenous gene promoter. Western blot analysis and in situ hybridization confirms absence of expression of the endogenous gene. (J:95332)

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pbrm1 Mutation: 91 strains or lines available

References

• Original: J:95332 Wang Z, et al., Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Genes Dev. 2004 Dec 15;18(24):3106-16
• All: 2 reference(s)