Sod1^tm1Ysh
Targeted Allele Detail

Summary

• Symbol: Sod1^tm1Ysh
• Name: superoxide dismutase 1, soluble; targeted mutation 1, Ye-Shih Ho
• MGI ID: MGI:3526701
• Synonyms: Sod1^-
• Gene: Sod1 Location: Chr16:90017650-90023221 bp, + strand Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
• Alliance: Sod1^tm1Ysh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46672
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was replaced with a neomycin resistance gene. mRNA could not be detected in the tissues of homozygous mice. (J:46672)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sod1 Mutation: 39 strains or lines available

References

• Original: J:46672 Ho YS, et al., Reduced fertility in female mice lacking copper-zinc superoxide dismutase. J Biol Chem. 1998 Mar 27;273(13):7765-9
• All: 13 reference(s)