Hmox1^tm1Ysh
Targeted Allele Detail

Summary

• Symbol: Hmox1^tm1Ysh
• Name: heme oxygenase 1; targeted mutation 1, Ye-Shih Ho
• MGI ID: MGI:3526703
• Gene: Hmox1 Location: Chr8:75820249-75827217 bp, + strand Genetic Position: Chr8, 35.59 cM, cytoband C1
• Alliance: Hmox1^tm1Ysh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95461
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 3 was replaced with a neomycin resistance gene. (J:95461)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmox1 Mutation: 35 strains or lines available

References

• Original: J:95461 Yoshida T, et al., H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: A study with transgenic mice heterozygous for targeted disruption of the Heme oxygenase-1 gene. Circulation. 2001 Mar 27;103(12):1695-701
• All: 1 reference(s)