Slc6a1^tm1.1Lst
Targeted Allele Detail

Summary

• Symbol: Slc6a1^tm1.1Lst
• Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1; targeted mutation 1.1, Henry A Lester
• MGI ID: MGI:3526736
• Gene: Slc6a1 Location: Chr6:114259735-114294491 bp, + strand Genetic Position: Chr6, 53.05 cM, cytoband E3
• Alliance: Slc6a1^tm1.1Lst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80438
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The floxed neomycin cassette in intron 14 was removed via cre mediated recombination. A GFP gene was inserted in exon 15 at the 3' end of the coding sequence. Expression of the GFP fusion protein is similar to wild-type. (J:80438)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a1 Mutation: 51 strains or lines available

References

• Original: J:80438 Chiu CS, et al., Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. J Neurosci. 2002 Dec 1;22(23):10251-66
• All: 1 reference(s)