Matk^tm1Sor
Targeted Allele Detail

Summary

• Symbol: Matk^tm1Sor
• Name: megakaryocyte-associated tyrosine kinase; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:3526800
• Synonyms: Matk/CHK^-
• Gene: Matk Location: Chr10:81088769-81098819 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Matk^tm1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109203
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A DNA fragment of approximately 500 bp that includes exon 7, which encodes a peptide sequence essential for ATP binding, has been replaced by a neomycin resistance cassette. (J:109203)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Matk Mutation: 30 strains or lines available

References

• Original: J:109203 Lee BC, et al., Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice. Blood. 2006 Aug 1;108(3):904-7
• All: 2 reference(s)