Efnb2^tm1Sor
Targeted Allele Detail

Summary

• Symbol: Efnb2^tm1Sor
• Name: ephrin B2; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:3526816
• Synonyms: Efnb2^F5
• Gene: Efnb2 Location: Chr8:8667434-8711242 bp, - strand Genetic Position: Chr8, 3.42 cM
• Alliance: Efnb2^tm1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143845
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A partial cDNA of a mutant version of mouse Efnb2 in which all tyrosine residues were mutated to phenylalanines was fused to exon 1. This cDNA was followed by a poly a signal and a floxed PGK-neo cassette. The floxed neo cassette was then removed by Cre mediated recombination. This mutation prevents tyrosine phosphorylation of the resulting protein. Expression of GFP was identical to endogenous expression in all tissues examined. (J:143845)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb2 Mutation: 29 strains or lines available

References

• Original: J:143845 Davy A, et al., Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development. Dev Biol. 2007 Apr 1;304(1):182-93
• All: 1 reference(s)