Krt90^whnl
Spontaneous Allele Detail

Summary

• Symbol: Krt90^whnl
• Name: keratin 90; witch nails
• MGI ID: MGI:3526848
• Gene: Krt90 Location: Chr15:101460791-101471385 bp, - strand Genetic Position: Chr15, 56.9 cM
• Alliance: Krt90^whnl page

Rear paw of Krt90^whnl/Krt90^whnl mouse showing very long nails

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: MRL/MpJ-Fas^lpr/J

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Duplication
• Mutation details: This spontaneous 7 base pair duplication insertion of AGCCTGT in exon 9 causes a serine to arginine substitution at amino acid 476 followed by a frameshift leading to 36 novel amino acids and then a premature stop codon. (J:222308)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Krt90 Mutation: 29 strains or lines available

References

• Original: J:223505 Ward-Bailey PF, et al., Witch nails (whnl): a new spontaneous mutation that causes very long toenails. MGI Direct Data Submission. 2015
• All: 3 reference(s)