Sgpl1^{Gt(ROSA)78Sor}
Gene trapped Allele Detail

Summary

• Symbol: Sgpl1^{Gt(ROSA)78Sor}
• Name: sphingosine phosphate lyase 1; gene trapped 78, Philippe Soriano
• MGI ID: MGI:3526851
• Synonyms: Sgpl1^-
• Gene: Sgpl1 Location: Chr10:60934421-60983463 bp, - strand Genetic Position: Chr10, 32.14 cM
• Alliance: Sgpl1^{Gt(ROSA)78Sor} page

Mutation origin

• Mutant Cell Line: S6-4D1
• Germline Transmission: Earliest citation of germline transmission: J:117491
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: ROSAFARY
• Mutation details: The Rosafary gene trap vector containing a SAbetaGeo pA promoter trap module and a PGKhygSD poly-A trap module was inserted into intron 2. (J:117491)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  FHCRC-GT-S6-4D1	CG784184 ; (MGI Seq Detail)	3' RACE	Chr10:60953515-60982109 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  16 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sgpl1 Mutation: 33 strains or lines available

References

• Original: J:117131 Oskouian B, et al., Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17384-9
• All: 19 reference(s)