Gata4^tm1Wtp
Targeted Allele Detail

Summary

• Symbol: Gata4^tm1Wtp
• Name: GATA binding protein 4; targeted mutation 1, William T Pu
• MGI ID: MGI:3526853
• Synonyms: GATA4^H
• Gene: Gata4 Location: Chr14:63436371-63509141 bp, - strand Genetic Position: Chr14, 33.24 cM
• Alliance: Gata4^tm1Wtp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94637
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: An Frt-flanked neo was inserted into intron 2, which contains the ATG. LoxP sites were inserted into the 5' UTR of exon 2 and downstream of the Frt-flanked neo. Detailed analysis showed this to be a severe hypomorhic allele. (J:94637)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata4 Mutation: 36 strains or lines available

References

• Original: J:94637 Pu WT, et al., GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol. 2004 Nov 1;275(1):235-44
• All: 2 reference(s)