Gata4^tm1.1Wtp
Targeted Allele Detail

Summary

• Symbol: Gata4^tm1.1Wtp
• Name: GATA binding protein 4; targeted mutation 1.1, William T Pu
• MGI ID: MGI:3526854
• Synonyms: Gata4^flox
• Gene: Gata4 Location: Chr14:63436371-63509141 bp, - strand Genetic Position: Chr14, 33.24 cM
• Alliance: Gata4^tm1.1Wtp page

Growth retardation and myocardial thinning in Gata4^tm1.1Wtp/Gata4^tm1Grg Tg(Nkx2-5-cre)9Eno/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94637
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: Gata4^tm1Wtp mice were crossed with Tg(ACTFLPe)9205Dym to remove the neo, leaving exon 2 floxed. Detailed analysis showed this to be a mild hypomorphic allele. (J:94637)

Expression

In Mice Carrying this Mutation:	85 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata4 Mutation: 36 strains or lines available

References

• Original: J:94637 Pu WT, et al., GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol. 2004 Nov 1;275(1):235-44
• All: 28 reference(s)