Tiparp^{Gt(ROSA)79Sor}
Gene trapped Allele Detail

Summary

• Symbol: Tiparp^{Gt(ROSA)79Sor}
• Name: TCDD-inducible poly(ADP-ribose) polymerase; gene trapped 79, Philippe Soriano
• MGI ID: MGI:3526866
• Synonyms: Tiparp^-
• Gene: Tiparp Location: Chr3:65435868-65462939 bp, + strand Genetic Position: Chr3, 30.2 cM
• Alliance: Tiparp^{Gt(ROSA)79Sor} page

Mutation origin

• Mutant Cell Line: S4-9E1
• Germline Transmission: Earliest citation of germline transmission: J:117491
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: ROSAFARY
• Mutation details: The Rosafary gene trap vector containing a SAbetaGeo pA promoter trap module and a PGKhygSD poly-A trap module was inserted into intron 1. (J:117491)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  FHCRC-GT-S4-9E1	CG465978 ; (MGI Seq Detail)	3' RACE	Chr3:65438647-65438882 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  6 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tiparp^Gt(ROSA)79Sor/Tiparp^Gt(ROSA)79Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)
hm2	Tiparp^Gt(ROSA)79Sor/Tiparp^Gt(ROSA)79Sor	involves: 129S4/SvJaeSor
hm3	Tiparp^Gt(ROSA)79Sor/Tiparp^Gt(ROSA)79Sor	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6J
cx4	Pdgfrb^tm1Sor/Pdgfrb^+ Tiparp^Gt(ROSA)79Sor/Tiparp^Gt(ROSA)79Sor	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
cx5	Pdgfra^tm1Sor/Pdgfra^+ Tiparp^Gt(ROSA)79Sor/Tiparp^Gt(ROSA)79Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)
cx6	Plekha1^Gt(ROSA)82Sor/Plekha1^Gt(ROSA)82Sor Tiparp^Gt(ROSA)79Sor/Tiparp^+	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)
cx7	Pdgfra^tm2Sor/Pdgfra^+ Tiparp^Gt(ROSA)79Sor/Tiparp^Gt(ROSA)79Sor	involves: 129S4/SvJaeSor

Phenotypes:

Affected Systems	hm1		hm2	hm3	cx4	cx5	cx6	cx7
show or hide all annotated terms Sex:
cardiovascular system			√
abnormal blood vessel morphology			√
hemorrhage			√
craniofacial			√					√
abnormal neurocranium morphology			√
abnormal frontal bone morphology			√					√
small presphenoid bone			√
short premaxilla			√					√
short maxilla			√					√
short nasal bone			√					√
abnormal palate morphology			√
decreased palatine bone horizontal plate size			√
broad snout			√					√
short snout			√					√
digestive/alimentary system			√
abnormal palate morphology			√
decreased palatine bone horizontal plate size			√
endocrine/exocrine glands	√			√
increased corpora lutea number	√
increased tertiary ovarian follicle number	√
enlarged ovary	√
hemorrhagic ovary cyst	√
abnormal thymus involution				√
growth/size/body	√		√	√				√
short nasal bone			√					√
abnormal palate morphology			√
decreased palatine bone horizontal plate size			√
broad snout			√					√
short snout			√					√
enlarged ovary	√
hemorrhagic ovary cyst	√
increased susceptibility to weight loss				√
enlarged liver				√
hematopoietic system			√	√
abnormal thymus involution				√
anemia			√
decreased erythrocyte cell number			√
decreased hematocrit			√
decreased hemoglobin content			√
polychromatophilia			√
reticulocytosis			√
homeostasis/metabolism	√	√	√	√
increased blood urea nitrogen level			√
decreased fasting circulating glucose level				√
decreased circulating estradiol level	√	√
increased circulating alanine transaminase level				√
increased susceptibility to xenobiotic induced morbidity/mortality				√
increased physiological sensitivity to xenobiotic				√
immune system			√	√
abnormal thymus involution				√
kidney inflammation			√
liver/biliary system				√
enlarged liver				√
hepatic steatosis				√
liver degeneration				√
mortality/aging			√	√
increased susceptibility to xenobiotic induced morbidity/mortality				√
postnatal lethality			√
muscle			√
abnormal smooth muscle morphology			√
renal/urinary system			√
kidney inflammation			√
abnormal kidney morphology			√
abnormal renal glomerulus morphology			√
small kidney			√
pale kidney			√
reproductive system	√	√			√	√	N
reproductive system phenotype							N
increased corpora lutea number	√
increased tertiary ovarian follicle number	√
enlarged ovary	√
hemorrhagic ovary cyst	√
enlarged uterus	√
long gestation period	√
prolonged estrous cycle	√
female infertility					√	√
reduced female fertility	√
decreased litter size	√	√
respiratory system			√					√
short nasal bone			√					√
skeleton			√					√
abnormal skeleton morphology			√					√
abnormal neurocranium morphology			√
abnormal frontal bone morphology			√					√
small presphenoid bone			√
short premaxilla			√					√
short maxilla			√					√
short nasal bone			√					√
decreased palatine bone horizontal plate size			√
abnormal sternum morphology			√
asymmetric sternocostal joints			√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tiparp Mutation: 43 strains or lines available

References

• Original: J:117491 Schmahl J, et al., PDGF signaling specificity is mediated through multiple immediate early genes. Nat Genet. 2007 Jan;39(1):52-60
• All: 4 reference(s)