Fth1^tm1Kjt
Targeted Allele Detail

Summary

• Symbol: Fth1^tm1Kjt
• Name: ferritin heavy polypeptide 1; targeted mutation 1, Khristy J Thompson
• MGI ID: MGI:3526872
• Synonyms: HFRT^-
• Gene: Fth1 Location: Chr19:9957962-9962462 bp, + strand Genetic Position: Chr19, 6.23 cM, cytoband A-C
• Alliance: Fth1^tm1Kjt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158718
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette replacing exon 1. Absence of protein product was confirmed by immunohistochemistry. (J:158718)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fth1 Mutation: 14 strains or lines available

References

• Original: J:158718 Thompson K, et al., Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. J Neurosci Res. 2003 Jan 1;71(1):46-63
• All: 1 reference(s)