Icos^tm1Tkan
Targeted Allele Detail

Summary

• Symbol: Icos^tm1Tkan
• Name: inducible T cell co-stimulator; targeted mutation 1, T Kanai
• MGI ID: MGI:3526880
• Synonyms: ICOS^-, ICOS-KO
• Gene: Icos Location: Chr1:61017086-61039479 bp, + strand Genetic Position: Chr1, 30.6 cM
• Alliance: Icos^tm1Tkan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95728
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin-resistance gene replaced exon 2. Staining of splenic T cells from mutants confirmed the lack of protein expression. (J:95728)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icos Mutation: 37 strains or lines available

References

• Original: J:95728 Iiyama R, et al., The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches. Immunol Lett. 2003 Jul 3;88(1):63-70
• All: 8 reference(s)