Tlr1^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Tlr1^tm1Flv
• Name: toll-like receptor 1; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3526882
• Synonyms: TLR1^-
• Gene: Tlr1 Location: Chr5:65082022-65090906 bp, - strand Genetic Position: Chr5, 33.53 cM
• Alliance: Tlr1^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95726
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The entire gene was replaced by a neomycin resistance cassette. Rt-PCR confirmed the absence of transcription. (J:95726)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr1 Mutation: 52 strains or lines available

References

• Original: J:95726 Alexopoulou L, et al., Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med. 2002 Aug;8(8):878-84
• All: 3 reference(s)