Umod^tm1Xrw
Targeted Allele Detail

Summary

• Symbol: Umod^tm1Xrw
• Name: uromodulin; targeted mutation 1, Xue-Ru Wu
• MGI ID: MGI:3526897
• Synonyms: THP^-
• Gene: Umod Location: Chr7:119061931-119078485 bp, - strand Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
• Alliance: Umod^tm1Xrw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95431
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-4 and a 650 bp proximal promoter region were replaced with a neomycin cassette. RT-PCR and Northern blot analysis demonstrated the lack of transcript in mutant kidneys. Immunohistochemistry and Western blot showed that no protein was present in mutant mice. (J:95431)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Umod Mutation: 5 strains or lines available

References

• Original: J:95431 Mo L, et al., Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli. Am J Physiol Renal Physiol. 2004 Apr;286(4):F795-802
• All: 15 reference(s)