Sim1^tm1.1Az
Targeted Allele Detail

Summary

• Symbol: Sim1^tm1.1Az
• Name: single-minded family bHLH transcription factor 1; targeted mutation 1.1, Andrew R Zinn
• MGI ID: MGI:3526899
• Synonyms: Sim1^-
• Gene: Sim1 Location: Chr10:50770850-50865248 bp, + strand Genetic Position: Chr10, 24.87 cM, cytoband B3-B4
• Alliance: Sim1^tm1.1Az page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95410
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Part of exon 1, including the translation start site and the first 17 amino acids encoding the basic domain were deleted upon cre mediated excision of a floxed sequence encompassing the ATG and a neo inserted into intron 1. (J:95410)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sim1 Mutation: 52 strains or lines available

References

• Original: J:95410 Holder JL Jr, et al., Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E105-13
• All: 5 reference(s)