Map2k5^tm1Ctr
Targeted Allele Detail

Summary

• Symbol: Map2k5^tm1Ctr
• Name: mitogen-activated protein kinase kinase 5; targeted mutation 1, Cathy Tournier
• MGI ID: MGI:3526901
• Synonyms: mek5^-
• Gene: Map2k5 Location: Chr9:63071050-63285184 bp, - strand Genetic Position: Chr9, 33.96 cM
• Alliance: Map2k5^tm1Ctr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95388
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2 was interrupted with the insertion of a lacZ-neo cassette in frame. Staining demonstrated Beta-galactosidase expression was ubiquitous. (J:95388)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map2k5 Mutation: 38 strains or lines available

References

• Original: J:95388 Wang X, et al., Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway. Mol Cell Biol. 2005 Jan;25(1):336-45
• All: 3 reference(s)