W10q13^M16i
QTL Variant Detail

Summary

• QTL variant: W10q13^M16i
• Name: weight 10 weeks QTL 13; M16i
• MGI ID: MGI:3527062
• QTL: W10q13 Location: Chr9:63239711-120191934 bp Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: M16i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight at 10 weeks compared to L6. (J:87794)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

This allele may be consistent with a recessive or additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87794

More than 1000 animals from an (M16i x L6)F2 intercross were typed for 63 polymorphic markers over 19 autosomes to identify QTLs associated with growth traits. Body weight was measured at 21, 42, and 70 days of age. Tail length was measured at 70 days asan indicator of skeletal growth. Parental strain M16i exhibits high weight gain between 21 and 42 days of age while parental strain L6 exhibits low weight gain. LOD=3.3 was used as the cutoff for statistically significant linkage.

W10q13 and Tailaq2 map to an interval on mouse Chromosome 9 between D9Mit105 and D9Mit19 (LOD=5.7 and LOD=8.5, respectively). Both QTLs peak at 53.9 cM. The 1 LOD confidence interval for W10q13 spans 44.5 cM - 61.4 cM. M16i-derived alleles at W10q13 confer increased body weight at 3 weeks of age with recessive or additive inheritance. This locus explains 7% of the variance. The 1 LOD confidence interval of Tailaq2 spans 47 cM - 58.9 cM. L6-derived alleles at Tailaq2 confer increased tail length adjusted for 6 week body weightwith dominant inheritance. This locus explains 11.8% of the variance.

References

• Original: J:87794 Rocha JL, et al., A large-sample QTL study in mice: I. Growth. Mamm Genome. 2004 Feb;15(2):83-99
• All: 1 reference(s)