Adam8^tm1Bbl
Targeted Allele Detail

Summary

• Symbol: Adam8^tm1Bbl
• Name: a disintegrin and metallopeptidase domain 8; targeted mutation 1, Carl P Blobel
• MGI ID: MGI:3527133
• Synonyms: Adam8^-
• Gene: Adam8 Location: Chr7:139558845-139572475 bp, - strand Genetic Position: Chr7, 84.96 cM, cytoband F3-F5
• Alliance: Adam8^tm1Bbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95366
• Parent Cell Line: E14TG2aIV (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-Beta-galactosidase and neo cassette replaced the catalytic and disintegrin domains. Western blot analysis of lungs confirmed that Adam8 protein was abolished in mutant animals. X-gal staining showed that the endogenous promoter drove lacZ expression in lung tissue. (J:95366)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adam8 Mutation: 45 strains or lines available

References

• Original: J:95366 Kelly K, et al., Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice. Dev Dyn. 2005 Jan;232(1):221-31
• All: 16 reference(s)